Agent Name


CAS Number




Major Category



DMF; DMF (amide); DMFA; Dimethyl formamide; Dimethylamid kyseliny mravenci [Czech]; Dimethylformamid [German]; Dimethylformamide; Dimetilformamide [Italian]; Dimetylformamidu [Czech]; Dwumetyloformamid [Polish]; Formamide, N,N-dimethyl-; Formic acid, amide, N,N-dimethyl-; N,N-Dimethyl formamide; N,N-Dimethylformamide; N,N-Dimethylmethanamide; N,N-Dimetilformamida [Spanish]; N-Formyldimethylamine; U-4224; [ChemIDplus] UN2265


Amides (<C10)


Colorless to pale-yellow liquid with a faint, amine-like odor; [NIOSH]


Used as a solvent in acrylic fiber spinning, textile dyeing, and paint stripping; also used in coating, printing, gluing, and pharmaceutical manufacturing; [] Used as a solvent for vinyl resins; [Kanerva, p. 1786] Used in synthetic leather manufacturing; [JOEM 2004;46:729-736]


Liquid causes first degree burns on short exposure; [CHRIS] Contact dermatitis reported in epoxy resin handler; Also can provoke alcohol-induced flushing; [Kanerva, p. 1786] DMF is toxic to the liver. [Reference #1] May cause liver injury and jaundice; [ICSC] Animals exposed to single lethal doses have CNS depression, anesthesia, convulsions, and coma. [HSDB] In the list of 15 chemicals classified as potentially fetotoxic even if MAK value observed; [Reference #2] Detailed reviews of these data indicate adverse effects on reproductive and teratogenic endpoints, but only at maternal toxicity. [ACGIH] See "Carcinogenicity of some industrial chemicals," Volume 115. [IARC, News Release, 23 February 2016] The BEI for Total N-methylformamide (NMF), which represents the sum of N-methylformamide (NMF) and N-(hydroxymethyl)-N-methylformamide (HMMF), is intended to protect almost all workers from liver damage due to exposure to N,N-dimethylformamide (DMF) by all routes of exposure." [ACGIH: BEI Documentation]

Reference Link

Preventing Adverse Health Effects from Exposure to Dimethylformamide (DMF)

Exposure Assessment

N-Methylformamide in urine = 30 mg/L at end of shift; N-Acetyl-S-(N-methylcarbamoyl)cysteine in urine = 30 mg/L at end of shift at end of workweek; [TLVs and BEIs]

Skin Designation (ACGIH)



5 ppm


10 ppm


5 ppm


500 ppm

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH: The chosen IDLH is based on the statements by Clayton et al. [1963] that rats survived a 4hour exposure to air saturated with dimethylformamide vapor [Smyth and Carpenter 1948] and inhalation of saturated vapors for 6 hours was lethal [Haskell Laboratory]. A.D. Little reports that the saturated concentration at 20 C is 3,550 ppm. Because exposures to rats for 4 hours were at saturated concentrations, 3,500 ppm is chosen as the IDLH. . . . Human data: None relevant for use in determining the revised IDLH.

Vapor Pressure

3.87 mm Hg

Odor Threshold Low

0.47 ppm

Odor Threshold High

100 ppm

Lethal Concentration

LCLo (rat) = 5,000 ppm/6 hr

Explanatory Notes

Flash point = 58 deg C, closed cup; [ACGIH] Odor threshold from AIHA;

Half Life

Whole body: 4 hours; [TDR, p. 551]

Reference Link

Reproductive toxicology in occupational settings: ...[Int Arch Occup Environ Health. 2006] - PubMed Result

Adverse Effects

CNS Solvent Syndrome


Hepatotoxin, Primary


Skin Burns

IARC Carcinogen

Probable Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information


Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap

Occupational diseases associated with exposure to this agent:


Industrial Processes with risk of exposure: